Liver epithelial focal adhesion kinase modulates fibrogenesis and hedgehog signaling

Liver epithelial focal adhesion kinase modulates fibrogenesis and hedgehog signaling

Focal adhesion kinase (FAK) is an important mediator of extracellular matrix–integrin mechano-signal transduction that regulates cell motility, survival, and proliferation. As such, FAK is being investigated as a potential therapeutic target for malignant and fibrotic diseases, and numerous clinical...

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Bibliographic Details
Main Authors: Yun Weng, Tyler J. Lieberthal, Vivian X. Zhou, Maya Lopez-Ichikawa, Manuel Armas-Phan, Tristan K. Bond, Miya C. Yoshida, Won-Tak Choi, Tammy T. Chang
Format: Article
Language:English
Published: American Society for Clinical investigation 2020-10-01
Series:JCI Insight
Subjects:
Cell biology
Hepatology
Online Access:https://doi.org/10.1172/jci.insight.141217

Internet

https://doi.org/10.1172/jci.insight.141217

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