Knockdown of ARHGAP24 reduces intimal hyperplasia through inhibiting the proliferation and phenotypic switching of smooth muscle cells possibly by inactivating both AKT and ERK1/2 signaling pathways

Knockdown of ARHGAP24 reduces intimal hyperplasia through inhibiting the proliferation and phenotypic switching of smooth muscle cells possibly by inactivating both AKT and ERK1/2 signaling pathways

Intimal hyperplasia is one of the common pathophysiological foundations of vascular remodeling including restenosis and atherosclerosis. The Rho GTPase activating protein 24 (ARHGAP24) has been reported as a tumor suppressor in multiple cancers. Nevertheless, the role of ARHGAP24 in intimal hyperpla...

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Bibliographic Details
Main Authors: Wei Liu, Jing Han, Qiuping Yang, Luoxing Xia, Cheng Chen, Jie Song, Yao Cai
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
Intimal hyperplasia
ARHGAP24
Vascular smooth muscle cell
Phenotypic switch
Proliferation
Differentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580823001723

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http://www.sciencedirect.com/science/article/pii/S2405580823001723

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