B-cell epitope discovery: The first protein flexibility-based algorithm–Zika virus conserved epitope demonstration

Antibody-antigen interaction–at antigenic local environments called B-cell epitopes–is a prominent mechanism for neutralization of infection. Effective mimicry, and display, of B-cell epitopes is key to vaccine design. Here, a physical approach is evaluated for the discovery of epitopes which evolve...

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Bibliographic Details
Main Authors: Daniel W. Biner, Jason S. Grosch, Peter J. Ortoleva
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016673/?tool=EBI