A Robust Method to Store Complement C3 With Superior Ability to Maintain the Native Structure and Function of the Protein

Complement components have a reputation to be very labile. One of the reasons for this is the spontaneous hydrolysis of the internal thioester that is found in both C3 and C4 (but not in C5). Despite the fact that ≈20,000 papers have been published on human C3 there is still no reliable method to st...

Full description

Bibliographic Details
Main Authors: Anna Adler, Vivek Anand Manivel, Karin Fromell, Yuji Teramura, Kristina N. Ekdahl, Bo Nilsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.891994/full