Cryo-EM structure of the folded-back state of human β-cardiac myosin

Cryo-EM structure of the folded-back state of human β-cardiac myosin

Abstract To save energy and precisely regulate cardiac contractility, cardiac muscle myosin heads are sequestered in an ‘off’ state that can be converted to an ‘on’ state when exertion is increased. The ‘off’ state is equated with a folded-back structure known as the interacting-heads motif (IHM), w...

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Bibliographic Details
Main Authors: Alessandro Grinzato, Daniel Auguin, Carlos Kikuti, Neha Nandwani, Dihia Moussaoui, Divya Pathak, Eaazhisai Kandiah, Kathleen M. Ruppel, James A. Spudich, Anne Houdusse, Julien Robert-Paganin
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38698-w

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https://doi.org/10.1038/s41467-023-38698-w

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