Improvement of Biocatalytic Properties and Cytotoxic Activity of L-Asparaginase from <i>Rhodospirillum rubrum</i> by Conjugation with Chitosan-Based Cationic Polyelectrolytes

Improvement of Biocatalytic Properties and Cytotoxic Activity of L-Asparaginase from <i>Rhodospirillum rubrum</i> by Conjugation with Chitosan-Based Cationic Polyelectrolytes

L-asparaginases (L-ASNases, EC 3.5.1.1) are a family of enzymes that are widely used for the treatment of lymphoblastic leukemias. L-ASNase from <i>Rhodospirillum rubrum</i> (RrA) has a low molecular weight, low glutaminase activity, and low immunogenicity, making it a promising enzyme f...

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Bibliographic Details
Main Authors: Natalia V. Dobryakova, Dmitry D. Zhdanov, Nikolay N. Sokolov, Svetlana S. Aleksandrova, Marina V. Pokrovskaya, Elena V. Kudryashova
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceuticals
Subjects:
L-asparaginase
<i>Rhodospirillum rubrum</i>
catalytic activity
cationic polymers
polyelectrolyte complexes
covalent conjugates
Online Access:https://www.mdpi.com/1424-8247/15/4/406

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https://www.mdpi.com/1424-8247/15/4/406

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