Synthesis, Cytotoxicity and Mechanistic Evaluation of 4-Oxoquinoline-3-carboxamide Derivatives: Finding New Potential Anticancer Drugs

Synthesis, Cytotoxicity and Mechanistic Evaluation of 4-Oxoquinoline-3-carboxamide Derivatives: Finding New Potential Anticancer Drugs

As part of a continuing search for new potential anticancer candidates, we describe the synthesis, cytotoxicity and mechanistic evaluation of a series of 4-oxoquinoline-3-carboxamide derivatives as novel anticancer agents. The inhibitory activity of compounds 10–18 was determined against three can...

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Bibliographic Details
Main Authors: Luana da S. M. Forezi, Nathalia M. C. Tolentino, Alessandra M. T. de Souza, Helena C. Castro, Raquel C. Montenegro, Rafael F. Dantas, Maria E. I. M. Oliveira, Floriano P. Silva, Jr., Leilane H. Barreto, Rommel M. R. Burbano, Bárbara Abrahim-Vieira, Riethe de Oliveira, Vitor F. Ferreira, Anna C. Cunha, Fernanda da C. S. Boechat, Maria Cecília B. V. de Souza
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Molecules
Subjects:
4-oxoquinoline
carboxamide
heterocycles
anticancer
Online Access:http://www.mdpi.com/1420-3049/19/5/6651

Internet

http://www.mdpi.com/1420-3049/19/5/6651

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