Multiplexing Iduronate-2-Sulphatase (MPS-II) into a 7-Plex Lysosomal Storage Disorder MS/MS Assay Using Cold-Induced Phase Separation

Multiplexing Iduronate-2-Sulphatase (MPS-II) into a 7-Plex Lysosomal Storage Disorder MS/MS Assay Using Cold-Induced Phase Separation

Mucopolysaccharidosis type II (MPS-II, Hunter syndrome, OMIM:30990) is a lysosomal storage disorder (LSD) that results in iduronate 2-sulphatase (I2S) enzyme deficiency. MPS-II was added to the Recommended Uniform Screening Panel (RUSP) in August 2022; thus, there is an increased demand for multiple...

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Bibliographic Details
Main Authors: Elya Courtney, C. Austin Pickens, Carla Cuthbert, Konstantinos Petritis
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Neonatal Screening
Subjects:
newborn screening
lysosomal storage disorder
Hunter syndrome
MPS-II
cold induced phase separation
Online Access:https://www.mdpi.com/2409-515X/9/2/32

Internet

https://www.mdpi.com/2409-515X/9/2/32

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