Delineating the activation mechanism and conformational landscape of a class B G protein-coupled receptor glucagon receptor

Delineating the activation mechanism and conformational landscape of a class B G protein-coupled receptor glucagon receptor

Class B G protein-coupled receptors (GPCRs) are important targets in the treatment of metabolic syndrome and diabetes. Although multiple structures of class B GPCRs–G protein complexes have been elucidated, the detailed activation mechanism of the receptors remains unclear. Here, we combine Gaussian...

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Bibliographic Details
Main Authors: Ying Wang, Mingyu Li, Wenqi Liang, Xinchao Shi, Jigang Fan, Ren Kong, Yaqin Liu, Jian Zhang, Ting Chen, Shaoyong Lu
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
GPCR
Molecular dynamics simulations
Markov state model
Allosteric modulator
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022000228

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http://www.sciencedirect.com/science/article/pii/S2001037022000228

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