Breathing new life into an old target: pulmonary disease drugs for Parkinson’s disease therapy

Abstract Increases in α-synuclein protein expression are suspected to increase the risk of the development of Parkinson’s disease (PD). A recent study has demonstrated that β2-adrenergic receptor (β2AR) agonists decrease histone acetylation in the α-synuclein gene and suppress transcription. Coupled...

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Bibliographic Details
Main Authors: Hisham Abdelmotilib, Andrew B. West
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Genome Medicine
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13073-017-0483-4