Jiyuan Oridonin A Overcomes Differentiation Blockade in Acute Myeloid Leukemia Cells With MLL Rearrangements via Multiple Signaling Pathways

Jiyuan Oridonin A Overcomes Differentiation Blockade in Acute Myeloid Leukemia Cells With MLL Rearrangements via Multiple Signaling Pathways

Differentiation therapy with all-trans-retinoic acid (ATRA) in acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML), has been extremely successful in inducing clinical remission in APL patients. However, the differentiation therapy of ATRA-based treatment has not been effect...

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Bibliographic Details
Main Authors: Mei Qu, Yu Duan, Min Zhao, Zhanju Wang, Mengjie Zhao, Yao Zhao, Haihua Wang, Yu Ke, Ying Liu, Hong-Min Liu, Liuya Wei, Zhenbo Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
differentiation therapy
acute myeloid leukemia with MLL gene rearrangements
Jiyuan oridonin A
martens tretinoin response up pathway
hematopoietic cell lineage pathway
cell adhesion pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.659720/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.659720/full

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