Toxicity study in a pig model of intraperitoneal collagenase as an “enzymatic scalpel” directed to break stroma in order to generate a new perspective for peritoneal carcinomatosis approach: an experimental research

Abstract Background This study aimed to measure the toxicity resulting from collagenase administration to the peritoneal cavity in a pig model as a preliminary step to break down the stroma surrounding tumors. Methods Eight pigs were treated with 2 different collagenase concentrations previously tes...

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Bibliographic Details
Main Authors: M. Garcia-Arranz, P. Villarejo-Campos, J. Barambio, S. Garcia Gomez-Heras, L. Vega-Clemente, H. Guadalajara, D. García-Olmo
Format: Article
Language:English
Published: BMC 2022-02-01
Series:World Journal of Surgical Oncology
Online Access:https://doi.org/10.1186/s12957-022-02524-2