Computational Insights into The Neuroprotective Action of Riluzole on 3-Acetylpyridine-Induced Ataxia in Rats

Computational Insights into The Neuroprotective Action of Riluzole on 3-Acetylpyridine-Induced Ataxia in Rats

Objective: Intra-peritoneal administration of riluzole has been shown to preserve the membrane properties and firing characteristics of Purkinje neurons in a rat model of cerebellar ataxia induced by 3-acetylpyridine (3-AP). However, the exact mechanism(s) by which riluzole restores the normal elect...

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Bibliographic Details
Main Authors: Mahyar Janahmadi, Amin Mahnam, Mehdi Edrisi, Samira Abbasi
Format: Article
Language:English
Published: Royan Institute (ACECR), Tehran 2013-01-01
Series:Cell Journal
Subjects:
Ataxia
Riluzole
Potassium Channels
Neuroprotection
Computer Simulation
Online Access:http://celljournal.org/library/upload/article/af_3244687246357223522425358263352743365222abbasi-1.pdf

Internet

http://celljournal.org/library/upload/article/af_3244687246357223522425358263352743365222abbasi-1.pdf

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