GBA1 as a risk gene for osteoporosis in the specific populations and its role in the development of Gaucher disease

GBA1 as a risk gene for osteoporosis in the specific populations and its role in the development of Gaucher disease

Abstract Background Osteoporosis and its primary complication, fragility fractures, contribute to substantial global morbidity and mortality. Gaucher disease (GD) is caused by glucocerebrosidase (GBA1) deficiency, leading to skeletal complications. This study aimed to investigate the impact of the G...

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Bibliographic Details
Main Authors: Chung-Hsing Wang, Yu‐Nan Huang, Wen-Ling Liao, Ai-Ru Hsieh, Wei-De Lin, Kai-Wen Liu, Wen-Li Lu, Chieh‐Chen Huang, Yin-Hsiu Chien, Ni-Chung Lee, Pen-Hua Su, Fuu-Jen Tsai
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Orphanet Journal of Rare Diseases
Subjects:
Gaucher disease
GBA1
Osteoclastogenesis
Inflammasome
Endoplasmic reticulum stress
Osteoporosis
Online Access:https://doi.org/10.1186/s13023-024-03132-x

Internet

https://doi.org/10.1186/s13023-024-03132-x

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