Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer’s disease-related inhibitory circuit dysfunction in adults with Down syndrome

Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer’s disease-related inhibitory circuit dysfunction in adults with Down syndrome

Abstract Background Alzheimer’s disease (AD) is the major cause of death in adults with Down syndrome (DS). There is an urgent need for objective markers of AD in the DS population to improve early diagnosis and monitor disease progression. NPTX2 has recently emerged as a promising cerebrospinal flu...

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Bibliographic Details
Main Authors: Olivia Belbin, Mei-Fang Xiao, Desheng Xu, Maria Carmona-Iragui, Jordi Pegueroles, Bessy Benejam, Laura Videla, Susana Fernández, Isabel Barroeta, Raúl Nuñez-Llaves, Victor Montal, Eduard Vilaplana, Miren Altuna, Jordi Clarimón, Daniel Alcolea, Rafael Blesa, Alberto Lleó, Paul F. Worley, Juan Fortea
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Molecular Neurodegeneration
Subjects:
Neuronal Pentraxin-2
Alzheimer’s disease
Down syndrome
Inhibitory circuits
Cerebrospinal fluid
Biomarker
Online Access:http://link.springer.com/article/10.1186/s13024-020-00398-0

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http://link.springer.com/article/10.1186/s13024-020-00398-0

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