Orthoflaviviral Inhibitors in Clinical Trials, Preclinical In Vivo Efficacy Targeting NS2B-NS3 and Cellular Antiviral Activity via Competitive Protease Inhibition

Orthoflaviviral Inhibitors in Clinical Trials, Preclinical In Vivo Efficacy Targeting NS2B-NS3 and Cellular Antiviral Activity via Competitive Protease Inhibition

Orthoflaviviruses, including zika (ZIKV), West Nile (WNV), and dengue (DENV) virus, induce severely debilitating infections and contribute significantly to the global disease burden, yet no clinically approved antiviral treatments exist. This review offers a comprehensive analysis of small-molecule...

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Bibliographic Details
Main Authors: Lorenzo Cavina, Mathijs J. Bouma, Daniel Gironés, Martin C. Feiters
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Molecules
Subjects:
orthoflavivirus
dengue virus
zika virus
West Nile virus
protease
NS2B-NS3 inhibitor
Online Access:https://www.mdpi.com/1420-3049/29/17/4047

Internet

https://www.mdpi.com/1420-3049/29/17/4047

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