A Haptoglobin Exon Copy Number Variant Associates With HIV-Associated Neurocognitive Impairment in European and African-Descent Populations

A Haptoglobin Exon Copy Number Variant Associates With HIV-Associated Neurocognitive Impairment in European and African-Descent Populations

A common two-exon deletion distinguishes the gene encoding the free hemoglobin capturing protein—haptoglobin (HP)–into two alleles: HP1 and HP2. To evaluate the impact of this copy number variant (CNV) on neurocognitive impairment (NCI) in people living with HIV, we imputed this variant in 432 Europ...

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Bibliographic Details
Main Authors: Haimeng Bai, Harpreet Kaur, Asha R. Kallianpur, Todd Hulgan, Donald R. Franklin, Scott L. Letendre, Ronald J. Ellis, William S. Bush
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Genetics
Subjects:
haptoglobin
neurocognitive impairment
HIV
CHARTER
longitudinal
age
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.756685/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.756685/full

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