MicroRNA-122 Is More Effective than Rapamycin in Inhibition of Epithelial-mesenchymal Transition and mTOR Signaling Pathway in Triple Negative Breast Cancer

MicroRNA-122 Is More Effective than Rapamycin in Inhibition of Epithelial-mesenchymal Transition and mTOR Signaling Pathway in Triple Negative Breast Cancer

The fundamental mechanism responsible for the aggressiveness of metastatic cancers such as triple-negative breast cancer (TNBC) is the epithelial-mesenchymal transition (EMT). In cancer microenvironments, the Phosphoinositide 3-kinases (PI3K)-Akt- mammalian target of rapamycin (mTOR) signaling path...

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Bibliographic Details
Main Authors: Majdedin Ghalavand, Ruhollah Dorostkar, Hojat Borna, Samira Mohammadi-Yeganeh, Seyed Mahmood Hashemi
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2023-02-01
Series:Iranian Journal of Allergy, Asthma and Immunology
Subjects:
Cancer microenvironment
MIRN122 microRNA, human
Rapamycin
Triple-negative breast cancer
Signaling pathway
Online Access:https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3734

Internet

https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3734

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