Liposomal Form of 2,4-Dinitrophenol Lipophilic Derivatives as a Promising Therapeutic Agent for ATP Synthesis Inhibition

Liposomal Form of 2,4-Dinitrophenol Lipophilic Derivatives as a Promising Therapeutic Agent for ATP Synthesis Inhibition

Mitochondrial uncoupler 2,4-dinitrophenol (2,4-DNP) is a promising antidiabetic and antiobesity agent. Its clinical use is limited by a narrow dynamic range and accumulation in non-target sensitive organs, which results in whole-body toxicity. A liposomal formulation could enable the mentioned drawb...

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Bibliographic Details
Main Authors: Kseniya Yu. Vlasova, Petr Ostroverkhov, Daria Vedenyapina, Tamara Yakimova, Alla Trusova, Galina Yurievna Lomakina, Stepan Sergeevich Vodopyanov, Mikhail Grin, Natalia Klyachko, Vladimir Chekhonin, Maxim Abakumov
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Nanomaterials
Subjects:
obesity
non-alcoholic fatty liver disease
mitochondrial uncoupler
2,4-dinitrophenol
liposomes
ATP synthesis inhibition
Online Access:https://www.mdpi.com/2079-4991/12/13/2162

Internet

https://www.mdpi.com/2079-4991/12/13/2162

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