Single-nuclei RNA sequencing uncovers heterogenous transcriptional signatures in Parkinson’s disease associated with nuclear receptor-related factor 1 defect

Single-nuclei RNA sequencing uncovers heterogenous transcriptional signatures in Parkinson’s disease associated with nuclear receptor-related factor 1 defect

Previous studies have found that deficiency in nuclear receptor-related factor 1 (Nurr1), which participates in the development, differentiation, survival, and degeneration of dopaminergic neurons, is associated with Parkinson’s disease, but the mechanism of action is perplexing. Here, we first asce...

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Bibliographic Details
Main Authors: Piniel Alphayo Kambey, Wen-Ya Liu, Jiao Wu, Bakwatanisa Bosco, Iqra Nadeem, Kouminin Kanwore, Dian-Shuai Gao
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Neural Regeneration Research
Subjects:
6-hydroxydopamine; dopaminergic neurons; dopamine transporter; nuclear receptor-related factor 1; parkinson’s disease; proteomics analysis; seurat clustering; single-nuclei rna sequencing; substantia nigra; tyrosine hydroxylase
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=9;spage=2037;epage=2046;aulast=Kambey

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=9;spage=2037;epage=2046;aulast=Kambey

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