Cell adhesion heterogeneity reinforces tumour cell dissemination: novel insights from a mathematical model

Cell adhesion heterogeneity reinforces tumour cell dissemination: novel insights from a mathematical model

Abstract Background Cancer cell invasion, dissemination, and metastasis have been linked to an epithelial-mesenchymal transition (EMT) of individual tumour cells. During EMT, adhesion molecules like E-cadherin are downregulated and the decrease of cell-cell adhesion allows tumour cells to dissociate...

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Bibliographic Details
Main Authors: David Reher, Barbara Klink, Andreas Deutsch, Anja Voss-Böhme
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Biology Direct
Subjects:
Tumour invasion
EMT
Tumour heterogeneity
Metastasis
Mathematical model
Cellular automaton
Online Access:http://link.springer.com/article/10.1186/s13062-017-0188-z

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http://link.springer.com/article/10.1186/s13062-017-0188-z

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