Bee Venom Melittin Disintegrates the Respiration of Mitochondria in Healthy Cells and Lymphoblasts, and Induces the Formation of Non-Bilayer Structures in Model Inner Mitochondrial Membranes

Bee Venom Melittin Disintegrates the Respiration of Mitochondria in Healthy Cells and Lymphoblasts, and Induces the Formation of Non-Bilayer Structures in Model Inner Mitochondrial Membranes

In this paper, we examined the effects of melittin, a bee venom membrane-active peptide, on mitochondrial respiration and cell viability of healthy human lymphocytes (HHL) and Jurkat cells, as well as on lymphoblasts from acute human T cell leukemia. The viability of melittin-treated cells was relat...

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Bibliographic Details
Main Authors: Edward Gasanoff, Yipeng Liu, Feng Li, Paul Hanlon, Győző Garab
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondrial bioenergetics
melittin
cytotoxicity
respiratory control index
T cell leukemia
inner mitochondrial membranes
Online Access:https://www.mdpi.com/1422-0067/22/20/11122

Internet

https://www.mdpi.com/1422-0067/22/20/11122

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