Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus

Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus

Abstract Background Progesterone receptor (PGR) is a master regulator of uterine function through antagonistic and synergistic interplays with oestrogen receptors. PGR action is primarily mediated by activation functions AF1 and AF2, but their physiological significance is unknown. Results We report...

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Bibliographic Details
Main Authors: Shi Hao Lee, Chew Leng Lim, Wei Shen, Samuel Ming Xuan Tan, Amanda Rui En Woo, Yeannie H. Y. Yap, Caitlyn Ang Su Sian, Wilson Wen Bin Goh, Wei-Ping Yu, Li Li, Valerie C. L. Lin
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Biology
Subjects:
PGR
Activation function 1
Endometrium
ESR1
Genomic antagonism
Online Access:https://doi.org/10.1186/s12915-022-01410-3

Internet

https://doi.org/10.1186/s12915-022-01410-3

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