Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precursor cell remyelination

Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precursor cell remyelination

Ghorbani and colleagues describe versican-V1 as an inhibitor of remyelination using transgenic mice that illuminate new GFP + oligodendrocytes. Mechanisms of versican-V1 include the direct inhibition of oligodendrocytes, and elevating Th17 cells.

Bibliographic Details
Main Authors: Samira Ghorbani, Emily Jelinek, Rajiv Jain, Benjamin Buehner, Cenxiao Li, Brian M. Lozinski, Susobhan Sarkar, Deepak K. Kaushik, Yifei Dong, Thomas N. Wight, Soheila Karimi-Abdolrezaee, Geert J. Schenk, Eva M. Strijbis, Jeroen Geurts, Ping Zhang, Chang-Chun Ling, V. Wee Yong
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30032-0

Internet

https://doi.org/10.1038/s41467-022-30032-0

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