Synthesis and Structure–Activity Relationship of 2,6-Disubstituted Thiosemicarbazone Derivatives of Pyridine as Potential Antituberculosis Agents

Synthesis and Structure–Activity Relationship of 2,6-Disubstituted Thiosemicarbazone Derivatives of Pyridine as Potential Antituberculosis Agents

In this study, six new 2,6-disubstituted thiosemicarbazone derivatives of pyridine were synthesized (<b>4</b>–<b>9</b>), and their tuberculostatic activity was evaluated. All of them showed two- to eightfold higher activity (minimum inhibitory concentration (MIC) 0.5–4 µg/mL)...

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Bibliographic Details
Main Authors: Dagmara Ziembicka, Katarzyna Gobis, Małgorzata Szczesio, Andrzej Olczak, Ewa Augustynowicz-Kopeć, Agnieszka Głogowska, Izabela Korona-Głowniak, Krzysztof Bojanowski
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Materials
Subjects:
synthesis
pyridine
thiosemicarbazone
tuberculostatic activity
antimicrobial activity
cytotoxic activity
Online Access:https://www.mdpi.com/1996-1944/16/1/448

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https://www.mdpi.com/1996-1944/16/1/448

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