The IRAK-M death domain: a tale of three surfaces

The IRAK-M death domain: a tale of three surfaces

The anti-inflammatory interleukin-1 receptor associated kinase-M (IRAK-M) is a negative regulator of MyD88/IRAK-4/IRAK-1 signaling. However, IRAK-M has also been reported to activate NF-κB through the MyD88/IRAK-4/IRAK-M myddosome in a MEKK-3 dependent manner. Here we provide support that IRAK-M use...

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Bibliographic Details
Main Authors: Berke Gürkan, Hessel Poelman, Liza Pereverzeva, Danielle Kruijswijk, Alex F. de Vos, Anouk G. Groenen, Edgar E. Nollet, Kanin Wichapong, Esther Lutgens, Tom van der Poll, Jiangfeng Du, W. Joost Wiersinga, Gerry A. F. Nicolaes, Cornelis van ‘t Veer
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
IRAK-M
IRAK-3
myddosome
death domain
Toll-like receptors
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1265455/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1265455/full

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