Development of non-viral, ligand-dependent, EPHB4-specific chimeric antigen receptor T cells for treatment of rhabdomyosarcoma

Development of non-viral, ligand-dependent, EPHB4-specific chimeric antigen receptor T cells for treatment of rhabdomyosarcoma

Ephrin type-B receptor 4 (EPHB4), expressed in tumors including rhabdomyosarcoma, is a suitable target for chimeric antigen receptor (CAR)-T cells. Ligand-independent activation of EPHB4 causes cell proliferation and malignant transformation in rhabdomyosarcoma, whereas ligand-dependent stimulation...

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Bibliographic Details
Main Authors: Hiroshi Kubo, Shigeki Yagyu, Kayoko Nakamura, Kumiko Yamashima, Akimasa Tomida, Ken Kikuchi, Tomoko Iehara, Yozo Nakazawa, Hajime Hosoi
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
EPHB4
chimeric antigen receptor
CAR-T cell therapy
rhabdomyosarcoma
piggyBac transposon
stem cell memory-like T cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521000334

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http://www.sciencedirect.com/science/article/pii/S2372770521000334

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