Increased in vivo perpetuation of whole-heart ventricular arrhythmia in heterozygous Na+/Ca2+ exchanger knockout mice

Increased in vivo perpetuation of whole-heart ventricular arrhythmia in heterozygous Na+/Ca2+ exchanger knockout mice

Aims: Na+/Ca2+ exchanger (NCX) upregulation in cardiac diseases like heart failure promotes as an independent proarrhythmic factor early and delayed afterdepolarizations (EADs/DADs) on the single cell level. Consequently, NCX inhibition protects against EADs and DADs in isolated cardiomyocytes. We h...

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Bibliographic Details
Main Authors: Nils Bögeholz, Vincent Knappe, Paul Pauls, Jan S. Schulte, Joshua I. Goldhaber, Frank U. Müller, Georg Nickenig, Lars Eckardt, Jan W. Schrickel, Thomas Beiert
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:International Journal of Cardiology: Heart & Vasculature
Subjects:
Arrhythmia mechanisms
Antiarrhythmic strategies
Na+/Ca2+ exchanger
Ventricular arrhythmia
Online Access:http://www.sciencedirect.com/science/article/pii/S2352906722002172

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http://www.sciencedirect.com/science/article/pii/S2352906722002172

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