Dual RNA-seq to catalogue host and parasite gene expression changes associated with virulence of T. annulata-transformed bovine leukocytes: towards identification of attenuation biomarkers

Abstract The apicomplexan parasite Theileria annulata is transmitted by Hyalomma ticks and causes an acute lymphoproliferative disease that is invariably lethal in exotic cattle breeds. The unique ability of the schizont stage of T. annulata to transform infected leukocytes to a cancer-like phenotyp...

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Bibliographic Details
Main Authors: Khawla Elati, Shahin Tajeri, Isaiah Obara, Moez Mhadhbi, Erich Zweygarth, Mohamed Aziz Darghouth, Ard Menzo Nijhof
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-45458-9