Integrin adhesome axis inhibits the RPM-1 ubiquitin ligase signaling hub to regulate growth cone and axon development.

Integrin adhesome axis inhibits the RPM-1 ubiquitin ligase signaling hub to regulate growth cone and axon development.

Integrin signaling plays important roles in development and disease. An adhesion signaling network called the integrin adhesome has been principally defined using bioinformatics and cell-based proteomics. To date, the adhesome has not been studied using integrated proteomic and genetic approaches. H...

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Detalles Bibliográficos
Main Authors: Jonathan Amezquita, Muriel Desbois, Karla J Opperman, Joseph S Pak, Elyse L Christensen, Nikki T Nguyen, Karen Diaz-Garcia, Melissa A Borgen, Brock Grill
Formato: Artigo
Idioma:English
Publicado: Public Library of Science (PLoS) 2024-12-01
Series:PLoS Genetics
Acceso en liña:https://doi.org/10.1371/journal.pgen.1011496

Internet

https://doi.org/10.1371/journal.pgen.1011496

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