Adjusting perioperative methadone dose for elderly and fragile hip fracture patients (MetaHip-trial) – A statistical analysis plan for an adaptive dose-finding trial

Adjusting perioperative methadone dose for elderly and fragile hip fracture patients (MetaHip-trial) – A statistical analysis plan for an adaptive dose-finding trial

Background: The elderly population is expanding globally. This gives numerous challenges especially regarding hip fracture patients. In the US alone over 300.000 hip fracture patients are treated each year, and a large amount of those develop opoid addiction. Hip fractures require surgical intervent...

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Bibliographic Details
Main Authors: Andreas Kristian Pedersen, Kevin Heebøll Nygaard, Sofie Ronja Petersen, Kirsten Specht, Thomas Strøm, Caroline Margaret Moos, Helene Skjøt-Arkil, Jesper Ougaard Schønnemann
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Contemporary Clinical Trials Communications
Subjects:
Elderly
Fragile
Postoperative
Pain
Perioperative
Dose finding
Online Access:http://www.sciencedirect.com/science/article/pii/S2451865423001746

Internet

http://www.sciencedirect.com/science/article/pii/S2451865423001746

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