The newly proposed alanine aminotransferase to high-density lipoprotein cholesterol ratio has shown effectiveness in identifying non-alcoholic fatty liver disease

ObjectiveAlanine aminotransferase (ALT) and high-density lipoprotein cholesterol (HDL-C) are important predictive factors for non-alcoholic fatty liver disease (NAFLD). The aim of this study was to analyze the association between the ALT/HDL-C ratio and NAFLD.MethodsWe conducted a retrospective anal...

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Main Authors: Jiajun Qiu, Maobin Kuang, Ruijuan Yang, Changhui Yu, Shiming He, Guotai Sheng, Yang Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Endocrinology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1239398/full
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author Jiajun Qiu
Jiajun Qiu
Maobin Kuang
Maobin Kuang
Ruijuan Yang
Ruijuan Yang
Changhui Yu
Changhui Yu
Shiming He
Shiming He
Guotai Sheng
Guotai Sheng
Yang Zou
author_facet Jiajun Qiu
Jiajun Qiu
Maobin Kuang
Maobin Kuang
Ruijuan Yang
Ruijuan Yang
Changhui Yu
Changhui Yu
Shiming He
Shiming He
Guotai Sheng
Guotai Sheng
Yang Zou
author_sort Jiajun Qiu
collection DOAJ
description ObjectiveAlanine aminotransferase (ALT) and high-density lipoprotein cholesterol (HDL-C) are important predictive factors for non-alcoholic fatty liver disease (NAFLD). The aim of this study was to analyze the association between the ALT/HDL-C ratio and NAFLD.MethodsWe conducted a retrospective analysis of data from 14,251 individuals participating in the NAGALA project’s health screening program. The presence of NAFLD was diagnosed based on the participants’ alcohol consumption status and liver ultrasonography images. Multivariable logistic regression models were used to assess the association between the ALT/HDL-C ratio and NAFLD. Receiver operating characteristic (ROC) analysis was performed to determine and compare the effectiveness of ALT, HDL-C, the aspartate aminotransferase to HDL-C (AST/HDL-C) ratio, the gamma-glutamyl transferase to HDL-C (GGT/HDL-C) ratio and the ALT/HDL-C ratio in identifying NAFLD.ResultsWe observed a significant positive association between the ALT/HDL-C ratio and the prevalence of NAFLD. For each standard deviation (SD) increase in the ALT/HDL-C ratio, the adjusted odds ratio (OR) for NAFLD among the participants was 3.05 [95% confidence interval (CI): 2.63, 3.53], with the highest quartile of ALT/HDL-C ratio having a 9.96-fold increased risk compared to the lowest quartile. In further subgroup analyses stratified by gender, age, and waist circumference (WC), we observed a significantly higher risk of NAFLD associated with the ALT/HDL-C ratio among individuals aged ≥45 years, males, and those who were abdominal obesity. Furthermore, based on the results of ROC analysis, we found that the ALT/HDL-C ratio [area under the curves (AUC): 0.8553] was significantly superior to ALT, HDL-C, AST/HDL-C ratio and GGT/HDL-C ratio in identifying NAFLD (All Delong P<0.05); the threshold of suggested ALT/HDL-C ratio for identifying NAFLD was 15.97.ConclusionThis population-based study demonstrates a positive association between the ALT/HDL-C ratio and NAFLD. The ALT/HDL-C ratio can effectively identify individuals with NAFLD.
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spelling doaj.art-0c455dbeb7bd4dd89593b325ad1d443f2023-09-01T14:39:01ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-08-011410.3389/fendo.2023.12393981239398The newly proposed alanine aminotransferase to high-density lipoprotein cholesterol ratio has shown effectiveness in identifying non-alcoholic fatty liver diseaseJiajun Qiu0Jiajun Qiu1Maobin Kuang2Maobin Kuang3Ruijuan Yang4Ruijuan Yang5Changhui Yu6Changhui Yu7Shiming He8Shiming He9Guotai Sheng10Guotai Sheng11Yang Zou12Department of Internal Medicine, Medical College of Nanchang University, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi, ChinaJiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, ChinaDepartment of Internal Medicine, Medical College of Nanchang University, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi, ChinaJiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, ChinaDepartment of Internal Medicine, Medical College of Nanchang University, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi, ChinaDepartment of Endocrinology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, ChinaDepartment of Internal Medicine, Medical College of Nanchang University, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi, ChinaJiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, ChinaDepartment of Internal Medicine, Medical College of Nanchang University, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi, ChinaJiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, ChinaJiangxi Provincial Geriatric Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, ChinaJiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, ChinaJiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, ChinaObjectiveAlanine aminotransferase (ALT) and high-density lipoprotein cholesterol (HDL-C) are important predictive factors for non-alcoholic fatty liver disease (NAFLD). The aim of this study was to analyze the association between the ALT/HDL-C ratio and NAFLD.MethodsWe conducted a retrospective analysis of data from 14,251 individuals participating in the NAGALA project’s health screening program. The presence of NAFLD was diagnosed based on the participants’ alcohol consumption status and liver ultrasonography images. Multivariable logistic regression models were used to assess the association between the ALT/HDL-C ratio and NAFLD. Receiver operating characteristic (ROC) analysis was performed to determine and compare the effectiveness of ALT, HDL-C, the aspartate aminotransferase to HDL-C (AST/HDL-C) ratio, the gamma-glutamyl transferase to HDL-C (GGT/HDL-C) ratio and the ALT/HDL-C ratio in identifying NAFLD.ResultsWe observed a significant positive association between the ALT/HDL-C ratio and the prevalence of NAFLD. For each standard deviation (SD) increase in the ALT/HDL-C ratio, the adjusted odds ratio (OR) for NAFLD among the participants was 3.05 [95% confidence interval (CI): 2.63, 3.53], with the highest quartile of ALT/HDL-C ratio having a 9.96-fold increased risk compared to the lowest quartile. In further subgroup analyses stratified by gender, age, and waist circumference (WC), we observed a significantly higher risk of NAFLD associated with the ALT/HDL-C ratio among individuals aged ≥45 years, males, and those who were abdominal obesity. Furthermore, based on the results of ROC analysis, we found that the ALT/HDL-C ratio [area under the curves (AUC): 0.8553] was significantly superior to ALT, HDL-C, AST/HDL-C ratio and GGT/HDL-C ratio in identifying NAFLD (All Delong P<0.05); the threshold of suggested ALT/HDL-C ratio for identifying NAFLD was 15.97.ConclusionThis population-based study demonstrates a positive association between the ALT/HDL-C ratio and NAFLD. The ALT/HDL-C ratio can effectively identify individuals with NAFLD.https://www.frontiersin.org/articles/10.3389/fendo.2023.1239398/fullALT/HDL-C ratioalanine aminotransferase to high-density lipoprotein cholesterol rationon-alcoholic fatty liver diseaseNAFLDALT to HDL-C ratio
spellingShingle Jiajun Qiu
Jiajun Qiu
Maobin Kuang
Maobin Kuang
Ruijuan Yang
Ruijuan Yang
Changhui Yu
Changhui Yu
Shiming He
Shiming He
Guotai Sheng
Guotai Sheng
Yang Zou
The newly proposed alanine aminotransferase to high-density lipoprotein cholesterol ratio has shown effectiveness in identifying non-alcoholic fatty liver disease
Frontiers in Endocrinology
ALT/HDL-C ratio
alanine aminotransferase to high-density lipoprotein cholesterol ratio
non-alcoholic fatty liver disease
NAFLD
ALT to HDL-C ratio
title The newly proposed alanine aminotransferase to high-density lipoprotein cholesterol ratio has shown effectiveness in identifying non-alcoholic fatty liver disease
title_full The newly proposed alanine aminotransferase to high-density lipoprotein cholesterol ratio has shown effectiveness in identifying non-alcoholic fatty liver disease
title_fullStr The newly proposed alanine aminotransferase to high-density lipoprotein cholesterol ratio has shown effectiveness in identifying non-alcoholic fatty liver disease
title_full_unstemmed The newly proposed alanine aminotransferase to high-density lipoprotein cholesterol ratio has shown effectiveness in identifying non-alcoholic fatty liver disease
title_short The newly proposed alanine aminotransferase to high-density lipoprotein cholesterol ratio has shown effectiveness in identifying non-alcoholic fatty liver disease
title_sort newly proposed alanine aminotransferase to high density lipoprotein cholesterol ratio has shown effectiveness in identifying non alcoholic fatty liver disease
topic ALT/HDL-C ratio
alanine aminotransferase to high-density lipoprotein cholesterol ratio
non-alcoholic fatty liver disease
NAFLD
ALT to HDL-C ratio
url https://www.frontiersin.org/articles/10.3389/fendo.2023.1239398/full
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