The YTHDF1–TRAF6 pathway regulates the neuroinflammatory response and contributes to morphine tolerance and hyperalgesia in the periaqueductal gray

The YTHDF1–TRAF6 pathway regulates the neuroinflammatory response and contributes to morphine tolerance and hyperalgesia in the periaqueductal gray

Abstract Long-term use of opioids such as morphine has negative side effects, such as morphine analgesic tolerance and morphine-induced hyperalgesia (MIH). These side effects limit the clinical use and analgesic efficacy of morphine. Elucidation of the mechanisms and identification of feasible and e...

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Bibliographic Details
Main Authors: Handong Ouyang, Jianxing Zhang, Dongmei Chi, Kun Zhang, Yongtian Huang, Jingxiu Huang, Wan Huang, Xiaohui Bai
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Neuroinflammation
Subjects:
YTHDF1
TRAF6
Morphine tolerance
Morphine-induced hyperalgesia
Inflammatory factors
Online Access:https://doi.org/10.1186/s12974-022-02672-y

Internet

https://doi.org/10.1186/s12974-022-02672-y

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