Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions

Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions

The polyamines, spermine (Spm) and spermidine (Spd), are important for cell growth and function. Their homeostasis is strictly controlled, and a key downregulator of the polyamine pool is the polyamine-inducible protein, antizyme 1 (OAZ1). OAZ1 inhibits polyamine uptake and targets ornithine decarbo...

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Bibliographic Details
Main Authors: Mervi T. Hyvönen, Olga A. Smirnova, Vladimir A. Mitkevich, Vera L. Tunitskaya, Maxim Khomutov, Dmitry S. Karpov, Sergey P. Korolev, Merja R. Häkkinen, Marko Pietilä, Marina B. Gottikh, Jouko Vepsäläinen, Leena Alhonen, Alexander A. Makarov, Sergey N. Kochetkov, Heather M. Wallace, Tuomo A. Keinänen, Alex R. Khomutov
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
polyamines
antizyme
dimerization
polyamine analogues
ribosomal frameshifting
polyamine uptake
Online Access:https://www.mdpi.com/1422-0067/23/9/4614

Internet

https://www.mdpi.com/1422-0067/23/9/4614

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