Integrated analysis of single-cell and bulk transcriptome reveals hypoxia-induced immunosuppressive microenvironment to predict immunotherapy response in high-grade serous ovarian cancer

Integrated analysis of single-cell and bulk transcriptome reveals hypoxia-induced immunosuppressive microenvironment to predict immunotherapy response in high-grade serous ovarian cancer

BackgroundHypoxia is significantly associated with cancer progression and treatment outcomes. Nevertheless, the precise molecular mechanisms underlying the hypoxia-induced immunosuppressive microenvironment in high-grade serous ovarian cancer (HGSOC) are still not fully understood.MethodsBy analyzin...

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Bibliographic Details
Main Authors: Qingshan Chen, Yue Zhang, Chao Wang, Hui Ding, Liqun Chi
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pharmacology
Subjects:
high-grade serous ovarian cancer
hypoxia
immunotherapy
immunosuppressive microenvironment
single-cell analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1450751/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1450751/full

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