Technologies for the Synthesis of mRNA-Encoding Libraries and Discovery of Bioactive Natural Product-Inspired Non-Traditional Macrocyclic Peptides

Technologies for the Synthesis of mRNA-Encoding Libraries and Discovery of Bioactive Natural Product-Inspired Non-Traditional Macrocyclic Peptides

In this review, we discuss emerging technologies for drug discovery, which yields novel molecular scaffolds based on natural product-inspired non-traditional peptides expressed using the translation machinery. Unlike natural products, these technologies allow for constructing mRNA-encoding libraries...

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Bibliographic Details
Main Authors: Hiroaki Suga, Toby Passioura, Kenichiro Ito
Format: Article
Language:English
Published: MDPI AG 2013-03-01
Series:Molecules
Subjects:
non-standard macrocyclic peptides
non-canonical amino acids
flexizyme
Random non-standard Peptide Integration Discovery (RaPID) system
peptide inhibitors
Online Access:http://www.mdpi.com/1420-3049/18/3/3502

Internet

http://www.mdpi.com/1420-3049/18/3/3502

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