Glycolytic flux-signaling controls mouse embryo mesoderm development

Glycolytic flux-signaling controls mouse embryo mesoderm development

How cellular metabolic state impacts cellular programs is a fundamental, unresolved question. Here, we investigated how glycolytic flux impacts embryonic development, using presomitic mesoderm (PSM) patterning as the experimental model. First, we identified fructose 1,6-bisphosphate (FBP) as an in v...

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Bibliographic Details
Main Authors: Hidenobu Miyazawa, Marteinn T Snaebjornsson, Nicole Prior, Eleni Kafkia, Henrik M Hammarén, Nobuko Tsuchida-Straeten, Kiran R Patil, Martin Beck, Alexander Aulehla
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-12-01
Series:eLife
Subjects:
metabolic signaling
flux-signaling metabolite
fructose 1,6-bisphosphate
Wnt signaling
subcellular protein localization
presomitic mesoderm
Online Access:https://elifesciences.org/articles/83299

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https://elifesciences.org/articles/83299

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