Interleukin-6 upregulates extracellular matrix gene expression and transforming growth factor β1 activity of tendon progenitor cells

Interleukin-6 upregulates extracellular matrix gene expression and transforming growth factor β1 activity of tendon progenitor cells

Abstract Background Prolonged inflammation during tendon healing and poor intrinsic healing capacity of tendon are causal factors associated with tendon structural and functional degeneration. Tendon cells, consisting of mature tenocytes and tendon progenitor cells (TPC) function to maintain tendon...

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Bibliographic Details
Main Authors: Nadine Altmann, Charles Bowlby, Haley Coughlin, Zarah Belacic, Stasia Sullivan, Sushmitha Durgam
Format: Article
Language:English
Published: BMC 2023-11-01
Series:BMC Musculoskeletal Disorders
Subjects:
Interleukin-6
Superficial digital flexor tendon
TGFβ1
ECM mRNA gene expression
Matrix metalloproteinases
Online Access:https://doi.org/10.1186/s12891-023-07047-9

Internet

https://doi.org/10.1186/s12891-023-07047-9

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