Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice

Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice

This study aimed to investigate the impact of caloric restriction (CR) on cognitive function in aged C57BL/6 mice after surgery, as well as the underlying mechanisms. Forty 14-month-old male C57BL/6 mice were randomly assigned to the ad libitum (AL, n = 20) group and the CR (n = 20) group. After fee...

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Bibliographic Details
Main Authors: Lan Wei, Qiang Tao, Minmin Yao, Zhimeng Zhao, Shengjin Ge
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Brain Sciences
Subjects:
calorie restriction (CR)
postoperative cognitive dysfunction (POCD)
silent information regulator 1 (Sirt1)
methyl CpG binding protein 2 (MeCP2)
brain derived neurotrophic factor (BDNF)
Online Access:https://www.mdpi.com/2076-3425/13/3/462

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https://www.mdpi.com/2076-3425/13/3/462

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