Dexamethasone impairs the expression of antimicrobial mediators in lipopolysaccharide-activated primary macrophages by inhibiting both expression and function of interferon β

Dexamethasone impairs the expression of antimicrobial mediators in lipopolysaccharide-activated primary macrophages by inhibiting both expression and function of interferon β

Glucocorticoids potently inhibit expression of many inflammatory mediators, and have been widely used to treat both acute and chronic inflammatory diseases for more than seventy years. However, they can have several unwanted effects, amongst which immunosuppression is one of the most common. Here we...

Full description

Bibliographic Details
Main Authors: John D. O’Neil, Oliwia O. Bolimowska, Sally A. Clayton, Tina Tang, Kalbinder K. Daley, Samuel Lara-Reyna, Jordan Warner, Claire S. Martin, Rahul Y. Mahida, Rowan S. Hardy, J. Simon C. Arthur, Andrew R. Clark
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
glucocorticoid
dexamethasone
macrophage
type I interferon
interferon β
innate immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1190261/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1190261/full

Similar Items