Crystallization of ApoA1 and ApoE4 Nanolipoprotein Particles and Initial XFEL-Based Structural Studies

Crystallization of ApoA1 and ApoE4 Nanolipoprotein Particles and Initial XFEL-Based Structural Studies

Nanolipoprotein particles (NLPs), also called “nanodiscs”, are discoidal particles with a patch of lipid bilayer corralled by apolipoproteins. NLPs have long been of interest due to both their utility as membrane-model systems into which membrane proteins can be inserted and solubilized and their ph...

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Bibliographic Details
Main Authors: Megan L. Shelby, Deepshika Gilbile, Thomas D. Grant, William J. Bauer, Brent Segelke, Wei He, Angela C. Evans, Natalia Crespo, Pontus Fischer, Tim Pakendorf, Vincent Hennicke, Mark S. Hunter, Alex Batyuk, Miriam Barthelmess, Alke Meents, Tonya L. Kuhl, Matthias Frank, Matthew A. Coleman
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Crystals
Subjects:
lipoprotein
nanodisc
serial femtosecond crystallography
XFELs
fixed target delivery
Online Access:https://www.mdpi.com/2073-4352/10/10/886

Internet

https://www.mdpi.com/2073-4352/10/10/886

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