Discovery of potent triterpenoid and limonoid compounds targeting Mycobacterium tuberculosis enoyl acyl carrier protein reductase (InhA): An in silico investigation

Discovery of potent triterpenoid and limonoid compounds targeting Mycobacterium tuberculosis enoyl acyl carrier protein reductase (InhA): An in silico investigation

Drug resistance remains one of the primary concerns in treating tuberculosis (TB), making it imperative to find new and effective drug candidates for improved TB treatment. Enoyl acyl carrier protein reductase (InhA), an enzyme involved in mycolic acid biosynthesis, is crucial for anti-TB drug activ...

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Bibliographic Details
Main Authors: Dian Ayu Eka Pitaloka, Arfan Arfan, Nayla Majeda Alfarafisa, Lidya Chaidir, Unang Supratman
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Informatics in Medicine Unlocked
Subjects:
Docking
Dynamics studies
Limonoid
Triterpenoid
Mycobacterium tuberculosis-Resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2352914823001454

Internet

http://www.sciencedirect.com/science/article/pii/S2352914823001454

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