Activation of ALOX12 by a multi-organelle-orienting photosensitizer drives ACSL4-independent cell ferroptosis

Activation of ALOX12 by a multi-organelle-orienting photosensitizer drives ACSL4-independent cell ferroptosis

Abstract Ferroptosis is a recently-defined tumor suppression mechanism, but the sensitivity of many tumorigenic cells to ferroptosis is limited by their deficient expression of acyl-CoA synthetase long-chain family member 4 (ACSL4). Here, we report the discovery of a photosensitizer, namely TPCI, wh...

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Bibliographic Details
Main Authors: Xiuxia Wang, Yuanhong Chen, Xiang Yang, Lianghui Cheng, Zhenyan He, Yanru Xin, Shan Huang, Fanling Meng, Peijing Zhang, Liang Luo
Format: Article
Language:English
Published: Nature Publishing Group 2022-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05462-9

Internet

https://doi.org/10.1038/s41419-022-05462-9

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