B-cell immunity and vaccine induced antibody protection reveal the inefficacy of current vaccination schedule in infants with perinatal HIV-infection in Mozambique, AfricaResearch in context

B-cell immunity and vaccine induced antibody protection reveal the inefficacy of current vaccination schedule in infants with perinatal HIV-infection in Mozambique, AfricaResearch in context

Summary: Background: Despite antiretroviral treatment (ART), immune dysfunction persists in children with perinatal HIV infection (HEI). Here we investigated the impact of HIV status on maternal antibody (Ab) passage, long-term vaccine induced immunity and B-cell maturation. Methods: 46 HIV Exposed...

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Bibliographic Details
Main Authors: Nicola Cotugno, Suresh Pallikkuth, Marco Sanna, Vinh Dinh, Lesley de Armas, Stefano Rinaldi, Sheldon Davis, Giulia Linardos, Giuseppe Rubens Pascucci, Rajendra Pahwa, Nadia Sitoe, Paula Vaz, Paolo Rossi, Maria Grazia Lain, Paolo Palma, Savita Pahwa
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:EBioMedicine
Subjects:
Pediatric HIV
Vaccine induced immunity
Tetanus responses
Memory B-Cells
B-cell aging
Double negative B-cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423002311

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http://www.sciencedirect.com/science/article/pii/S2352396423002311

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