An accurate strategy for pointing the key biocatalytic sites of bre2691A protein for modification of the brevilaterin from Brevibacillus laterosporus

An accurate strategy for pointing the key biocatalytic sites of bre2691A protein for modification of the brevilaterin from Brevibacillus laterosporus

Abstract Background Brevilaterin A-E, a novel class of multi-component cationic antimicrobial lipopeptides, were biosynthesized by a non-ribosomal peptides synthetase (NRPS) in Brevibacillus laterosporus. However, the antimicrobial abilities of different brevilaterin components varied greatly, and t...

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Bibliographic Details
Main Authors: Panpan Han, Zhou Chen, Yangliu Liu, Aijin Ma, Siting Li, Yingmin Jia
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Microbial Cell Factories
Subjects:
Biocatalytic
Adenylation domain
Cationic antimicrobial peptide
Brevibacillus laterosporus
Online Access:https://doi.org/10.1186/s12934-022-01918-x

Internet

https://doi.org/10.1186/s12934-022-01918-x

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