Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells
The transcriptional programs of nuclei in the muscle syncytium were assumed to be homogenous except at the neuromuscular and myotendinous junctions. Here, using single-nucleus transcriptomics, the authors reveal a previously unrecognized diversity and dynamics of myonuclear transcriptional programs.
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-12-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20064-9 |
| _version_ | 1818749510087606272 |
|---|---|
| author | Minchul Kim Vedran Franke Bettina Brandt Elijah D. Lowenstein Verena Schöwel Simone Spuler Altuna Akalin Carmen Birchmeier |
| author_facet | Minchul Kim Vedran Franke Bettina Brandt Elijah D. Lowenstein Verena Schöwel Simone Spuler Altuna Akalin Carmen Birchmeier |
| author_sort | Minchul Kim |
| collection | DOAJ |
| description | The transcriptional programs of nuclei in the muscle syncytium were assumed to be homogenous except at the neuromuscular and myotendinous junctions. Here, using single-nucleus transcriptomics, the authors reveal a previously unrecognized diversity and dynamics of myonuclear transcriptional programs. |
| first_indexed | 2024-12-18T04:04:55Z |
| format | Article |
| id | doaj.art-0c73b2a2ed2f4892ba50a3fd0390c9f8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:04:55Z |
| publishDate | 2020-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0c73b2a2ed2f4892ba50a3fd0390c9f82022-12-21T21:21:36ZengNature PortfolioNature Communications2041-17232020-12-0111111410.1038/s41467-020-20064-9Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cellsMinchul Kim0Vedran Franke1Bettina Brandt2Elijah D. Lowenstein3Verena Schöwel4Simone Spuler5Altuna Akalin6Carmen Birchmeier7Developmental Biology/Signal Transduction, Max Delbrueck Center for Molecular MedicineBerlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular MedicineDevelopmental Biology/Signal Transduction, Max Delbrueck Center for Molecular MedicineDevelopmental Biology/Signal Transduction, Max Delbrueck Center for Molecular MedicineMuscle Research Unit, Experimental and Clinical Research Center, Charité Universitätsmedizin Berlin and Max Delbrueck Center for Molecular MedicineMuscle Research Unit, Experimental and Clinical Research Center, Charité Universitätsmedizin Berlin and Max Delbrueck Center for Molecular MedicineBerlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular MedicineDevelopmental Biology/Signal Transduction, Max Delbrueck Center for Molecular MedicineThe transcriptional programs of nuclei in the muscle syncytium were assumed to be homogenous except at the neuromuscular and myotendinous junctions. Here, using single-nucleus transcriptomics, the authors reveal a previously unrecognized diversity and dynamics of myonuclear transcriptional programs.https://doi.org/10.1038/s41467-020-20064-9 |
| spellingShingle | Minchul Kim Vedran Franke Bettina Brandt Elijah D. Lowenstein Verena Schöwel Simone Spuler Altuna Akalin Carmen Birchmeier Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells Nature Communications |
| title | Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells |
| title_full | Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells |
| title_fullStr | Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells |
| title_full_unstemmed | Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells |
| title_short | Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells |
| title_sort | single nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells |
| url | https://doi.org/10.1038/s41467-020-20064-9 |
| work_keys_str_mv | AT minchulkim singlenucleustranscriptomicsrevealsfunctionalcompartmentalizationinsyncytialskeletalmusclecells AT vedranfranke singlenucleustranscriptomicsrevealsfunctionalcompartmentalizationinsyncytialskeletalmusclecells AT bettinabrandt singlenucleustranscriptomicsrevealsfunctionalcompartmentalizationinsyncytialskeletalmusclecells AT elijahdlowenstein singlenucleustranscriptomicsrevealsfunctionalcompartmentalizationinsyncytialskeletalmusclecells AT verenaschowel singlenucleustranscriptomicsrevealsfunctionalcompartmentalizationinsyncytialskeletalmusclecells AT simonespuler singlenucleustranscriptomicsrevealsfunctionalcompartmentalizationinsyncytialskeletalmusclecells AT altunaakalin singlenucleustranscriptomicsrevealsfunctionalcompartmentalizationinsyncytialskeletalmusclecells AT carmenbirchmeier singlenucleustranscriptomicsrevealsfunctionalcompartmentalizationinsyncytialskeletalmusclecells |