Reduction in cardiolipin reduces expression of creatine transporter-1 and creatine transport in growing hCMEC/D3 human brain microvessel endothelial cells

Reduction in cardiolipin reduces expression of creatine transporter-1 and creatine transport in growing hCMEC/D3 human brain microvessel endothelial cells

The phospholipid cardiolipin (CL) regulates mitochondrial energy production. Endothelial cells of the blood-brain barrier (BBB) play a vital role in uptake of metabolites into the brain and are enriched in mitochondria. We examined how deficiency in BBB endothelial cell CL regulates the expression o...

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Bibliographic Details
Main Authors: Donald W. Miller, Grant M. Hatch
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Drug Delivery
Subjects:
cardiolipin
blood brain barrier
mitochondria
creatine transporter 1
P-glycolprotein
breast cancer resistance protein
Online Access:https://www.frontiersin.org/articles/10.3389/fddev.2023.1158369/full

Internet

https://www.frontiersin.org/articles/10.3389/fddev.2023.1158369/full

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