Characterization of the PB2 Cap Binding Domain Accelerates Inhibitor Design

Characterization of the PB2 Cap Binding Domain Accelerates Inhibitor Design

X-ray crystallographic structural determinations of the PB2 cap binding domain (PB2cap) have improved the conformational characterization of the RNA-dependent RNA polymerase machinery (PA, PB2, and PB1) of the influenza virus. Geometrically, the catalytic PB1 subunit resembles the palm of a human ha...

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Bibliographic Details
Main Authors: Amanda E. Constantinides, Chelsea C. Severin, Ryan H. Gumpper, Xiaofeng Zheng, Ming Luo
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Crystals
Subjects:
cap-snatching
polymerase basic protein 2
RNA polymerase
domain movement
Online Access:http://www.mdpi.com/2073-4352/8/2/62

Internet

http://www.mdpi.com/2073-4352/8/2/62

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