Characterization of the PB2 Cap Binding Domain Accelerates Inhibitor Design
X-ray crystallographic structural determinations of the PB2 cap binding domain (PB2cap) have improved the conformational characterization of the RNA-dependent RNA polymerase machinery (PA, PB2, and PB1) of the influenza virus. Geometrically, the catalytic PB1 subunit resembles the palm of a human ha...
Main Authors: | Amanda E. Constantinides, Chelsea C. Severin, Ryan H. Gumpper, Xiaofeng Zheng, Ming Luo |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-01-01
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Series: | Crystals |
Subjects: | |
Online Access: | http://www.mdpi.com/2073-4352/8/2/62 |
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