Structural Insights into Plasticity and Discovery of Flavonoid Allosteric Inhibitors of Flavivirus NS2B–NS3 Protease

Structural Insights into Plasticity and Discovery of Flavonoid Allosteric Inhibitors of Flavivirus NS2B–NS3 Protease

Flaviviruses are among the most critical pathogens in tropical regions; they cause various severe diseases in developing countries but are not restricted to these countries. The development of antiviral therapeutics is crucial for managing flavivirus outbreaks. Ten proteins are encoded in the flaviv...

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Bibliographic Details
Main Authors: Marielena Vogel Saivish, Gabriela de Lima Menezes, Vivaldo Gomes da Costa, Liliane Nebo, Gislaine Celestino Dutra da Silva, Carolina Colombelli Pacca, Rafael Elias Marques, Maurício Lacerda Nogueira, Roosevelt Alves Da Silva
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biophysica
Subjects:
flaviviral protease inhibitors
Rocio virus
Ilhéus virus
Saint Louis encephalitis virus
yellow fever virus
3D pharmacophores
Online Access:https://www.mdpi.com/2673-4125/3/1/6

Internet

https://www.mdpi.com/2673-4125/3/1/6

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